After singing with the group that later became the Whispers, Brenda Holloway's first professional recording was made at age 14, backing 12-year-old Patrice on a locally released single. Brenda herself soon began cutting records on several different LA labels, and she and her sister also found work as session vocalists.
In 1964, Brenda performed a rendition of Mary Wells' 'My Guy' at a DJ convention in Los Angeles. Motown founder Berry Gordy happened to be there, and he was so struck by the power of her vocals that he made Holloway his first West Coast signing, placing her on the Tamla subsidiary.
Her debut single, 'Every Little Bit Hurts', was an R&B smash that also reached number 12 on the pop charts and was covered by British R&B aficionados like the Spencer Davis Group and Small Faces; it became the title track of her first album, also released in 1964. Brenda also found fans in the Beatles, who gave her an opening slot on their 1965 American tour.
She scored several more R&B hits through 1965 - 'I'll Always Love You' and the Smokey Robinson-penned tracks 'When I'm Gone' and 'Operator'. However, Tamla scrapped a follow-up album, which would have been called Hurtin' and Cryin', and Brenda began to feel that she was getting the short end of the stick. She frequently travelled from her home in Los Angeles to record in Detroit and began to feel that the material she was given wasn't always up to snuff, perhaps because of her distance.
She began to work more on her own writing, often in partnership with her sister, and with a bit of outside help they co-wrote 'You've Made Me So Very Happy' in 1968. Holloway's version was a minor R&B hit, but Blood Sweat & Tears turned it into a major pop hit the following year.
In 1995, motivated by the death of Mary Wells, she returned to live performance around the LA area, often in tandem with fellow soul veteran Brenton Wood.
She performed in the UK as well, and in 1999 she signed with the revived Volt label to record It's a Woman's World, which took a more contemporary urban approach.