The trio consisted of sisters Barbara Ann (born 23 October 1943) and Rosa Lee Hawkins (born 24 September 1944); plus their cousin Joan Marie Johnson (born 15 January 1945), from the Calliope housing project in New Orleans. They first sang together in grade school. Originally they were to be called Little Miss and the Muffets, but were named the Dixie Cups just prior to their first release.
By 1963 the trio had decided to pursue a career in music and began singing locally as the Meltones. Within a year Joe Jones, a successful singer in his own right with the Top Five 1960 single 'You Talk Too Much', became their manager. After working with them for five months, Jones took them to New York, where record producers/songwriters Jerry Leiber and Mike Stoller signed them to their new Red Bird Records. Their first release, 'Chapel of Love', proved to be their biggest hit, although they had other hits with 'People Say' (number twelve, 1964), 'You Should Have Seen the Way He Looked at Me' (number 39, 1964), 'Iko Iko' (number 20, 1965) and 'Little Bell' (number 51, 1965).
In 1966, the Dixie Cups were moved to the ABC-Paramount record label and later temporarily retired from the record industry.
On August 29, 2005, Hurricane Katrina swept through Louisiana, flooding and flattening most of New Orleans and displacing Barbara and Rosa Hawkins, who subsequently relocated to Florida. Joan Johnson relocated to Texas.
In April of 2007, the Louisiana Music Hall of Fame honoured the Dixie Cups for their contributions to Louisiana music by inducting them into the Louisiana Music Hall of Fame.